Application

Anti-Survivin Antibody is an antibody against Survivin for use in WB.

Research CategoryApoptosis & Cancer

Research Sub CategoryBCL2 & Inhibition

Western blot: 1:500 to 1:1000

Mouse spleen tissue lysate can be used as a positive control.

Optimal working dilutions must be determined by end user.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Apoptosis is triggered by a variety of stimuli, including members of the Tumor Necrosis Factor (TNF) family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. One of these IAP proteins, Survivin/TIAP, interacts with the processed form of caspase-3 and has been shown to inhibit its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Immunogen

Peptide corresponding to aa 128-140 of mouse survivin/TIAP.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Specificity

Detects mouse survivin/TIAP in an approximate 17 kDa band by western blot.

Storage and Stability

Maintain at 4°C for up to 6 months.